Welcome to the Combinatorial Biochemistry laboratory website. Our laboratory is located in the Institute of Chemistry at the University of São Paulo. In a few words, our group explores the universe of proteins, macromolecules that are essential for life, unveiling their structural and functional role in cells and the organism as a whole.
Although they are produced by the combination of only 20 amino acids, the number of different proteins that can be generated is almost infinite. To explore this vast universe, we use combinatorial methodologies to identify pairs of peptides and proteins biologically relevant in different human disease.
Our goal is to identify new molecular targets for the development of drugs. Among them, retinopathy, cancer and Chagas (a tropical neglected disease) are examples of human diseases that we are currently studying in our laboratory.